Total IgE Rapid Test

Description

Intended Use

Total IgE Rapid Test is an in-vitro rapid immunochromatographic assay for the qualitative detection of total immunoglobulin E(IgE) in Whole Blood/Serum/Plasma specimens from patients. Total IgE Rapid Test is intended to aid in the presumptive diagnosis of allergy.

Introduction

Immunoglobulin E (IgE) is a class of antibody (or immunoglobulin (Ig) “isotype”) that has been found only in mammals. IgE’s main function is immunity to parasites such as parasitic worms like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica. IgE may also be important during immune defense against certain protozoan parasites such as Plasmodium falciparum.

IgE also plays an essential role in type I hypersensitivity, which manifests various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergy, and some types of chronic urticaria and atopic dermatitis. IgE also plays a pivotal role in allergic conditions, such as anaphylactic reactions to certain drugs, pollen, and antigen preparations used in specific desensitization immunotherapy.

Although IgE is typically the least abundant isotype—blood serum IgE levels in a normal (“non-atopic”) individual are only 0.05% of the Ig concentration, compared to 75% for the IgGs at 10 mg/ml, which are the isotypes responsible for most of the classical adaptive immune response—it is capable of triggering the most powerful inflammation reactions.